Studii despre Albastrul de Metilen 2

  https://pubmed.ncbi.nlm.nih.gov/34019535/

Clinical Trial
 
. 2021;73(3):190-198.
 doi: 10.24875/RIC.21000028.

METHYLENE BLUE FOR TREATMENT OF HOSPITALIZED COVID-19 PATIENTS: A RANDOMIZED, CONTROLLED, OPEN-LABEL CLINICAL TRIAL, PHASE 2

Daryoush Hamidi-Alamdari 1, Saied Hafizi-Lotfabadi 2, Ahmad Bagheri-Moghaddam 3, Hossin Safari 4, Mahnaz Mozdourian 5, Zahra Javidarabshahi 5, Arash Peivandi-Yazdi 5, Abass Ali-Zeraati 6, Alireza Sedaghat 5, Farid Poursadegh 5, Fatemeh Barazandeh-Ahmadabadi 2, Marzieh Agheli-Rad 2, Seyed M Tavousi 6, Shohreh Vojouhi 7, Shahram Amini 8, Mahnaz Amini 5, Seyed Majid-Hosseini 9, Ashraf Tavanaee-Sani 10, Amin Ghiabi 11, Shima Nabavi-Mahalli 9, Negar Morovatdar 12, Omid Rajabi 13, George Koliakos 14
Affiliations 
Free article

Abstract

Background: There is no pharmacological intervention on the treatment of hypoxemia and respiratory distress in COVID-19 patients.

Objective: The objective of the study was to study the effect of the reduced form of methylene blue (MB) on the improvement of oxygen saturation (SpO2) and respiratory rate (RR).

Methods: In an academic medical center, 80 hospitalized patients with severe COVID-19 were randomly assigned to receive either oral MB along with standard of care (SOC) (MB group, n = 40) or SOC only (SOC group, n=40). The primary outcomes were SpO2 and RR on the 3rd and 5th days. The secondary outcomes were hospital stay and mortality within 28 days.

Results: In the MB group, a significant improvement in SpO2 and RR was observed on the 3rd day (for both, p < 0.0001) and also the 5th day (for both, p < 0.0001). In the SOC group, there was no significant improvement in SpO2 (p = 0.24) and RR (p = 0.20) on the 3rd day, although there was a significant improvement of SpO2 (p = 0.002) and RR (p = 0.01) on the 5th day. In the MB group in comparison to the SOC group, the rate ratio of increased SpO2 was 13.5 and 2.1 times on the 3rd and 5th days, respectively. In the MB group compared with the SOC group, the rate ratio of RR improvement was 10.1 and 3.7 times on the 3rd and 5th days, respectively. The hospital stay was significantly shortened in the MB group (p = 0.004), and the mortality was 12.5% and 22.5% in the MB and SOC groups, respectively.

Conclusions: The addition of MB to the treatment protocols significantly improved SpO2 and respiratory distress in COVID-19 patients, which resulted in decreased hospital stay and mortality. ClinicalTrials.gov: NCT04370288.

Keywords: COVID-19; Hypoxemia; Methylene Blue; Mortality; Treatment.

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