source: https://methylene-blue.conzapp.com/methylene-blue-dosage-for-patients-for-prophylaxis
Dr Golwalkar Methylene Blue therapy for patients & for Prophylaxis (prevention)
Many people have written asking for the dosage for MB(Methylene Blue) with nebulizer — so creating this post to help everyone in this time of need.
NOTE : Methylene Blue is very toxic in incorrect dosage and should only be taken under the supervision of a medical professional.
Dosage
MB shows best results when used as a prophylactic and in the early stages of the disease (when spO2 is above 92–93%). In severe cases its administration as an add on therapy improves final outcomes depending on the progress of the disease.
Dosage for Prophylaxis (i.e. for prevention)
MB shows best results as a prophylactic & should be considered as the primary line of treatment in the general unaffected population.
- Sublingual administration of 0.1% w/v concentration daily (till the pandemic lasts) — swallow what is not absorbed in approx. 30 seconds (2.5 ml) OD
- OR : If possible; 1.25 ML twice a day
Dosage for Patients
In affected patients in their early stage of the disease (spO2 more than 92%); Nebulized MB is a supportive line of treatment and has shown to improve the final clinical outcome.
- One ampule of Dexona + one ampule Duolin in nebulized form BD
- MB in nebulzed form 0.1% w/v of BD (NOT to be mixed with Dexona + Duolin) 5 ml b.d.
- Post recovery, continue to administer MB Nebulizer OD till 6 minute walk test is normal
Side Effects
- As MB has a strong blue color, the face will show blue coloration on Nebulization which is temporary
- MB has a bitter taste so some patients may complain of the same
- Some patients report a bluish green tinge in their urine
- Some patients may complain about irritation in the nose, nausea post nebulized administration
- In some cases patients will complain of irritation in the nose post nebulization
Important Notes / Contra Indications
- Methylene Blue is toxic in incorrect dosages so please do not self administer it (it should only be administered by a certified medical practitioner); dosage should be only as directed
- Methylene Blue must not be administered to pregnant or lactating mothers(it can be harmful to the fetus; data for feeding mothers is not available)
- Methylene Blue should not be administered who have known reported hypersensitivity to MB, G6PD deficiency, cronic/acute liver dysfunction, cyanide poisoning or severe renal impairment
- Methylene Blue should not be administered to children below 12 years of age (insufficient data available)
- Methylene Blue is an add on therapy to conventional line of treatment
- Only IP or USP grade Methylene Blue to be used
- Please note that this should be nebulized; it should NOT be inhaled with steam
Reactions with other medicines
References
- Cleaveland Clinic Reference on MB
- Click here to view original post of MB and its use against Covid
- Click here to view reasons MB is still not an approved drug of choice for Covid-19 prophylaxis
Can we use this one on Amazon as someone suggested – https://www.amazon.in/dp/B08GL3KFHP/ref=cm_sw_em_r_mt_dp_vChsFbQFXJBV3
Or can you suggest where can we get it in Mumbai, I could not find it in the nearby medical stores.
Yes it is correct; even I ordered the same and verified with the the staff at the clinic after receiving. Its correct.
How to prepare 0.1% MB? We have MB which is routinely used by surgeons, it doesn’t have any concentration label, what about sterility?
Please use IP grade only. Tablets and Injections are available and can be diluted to achieve 0.1% solution. The dilution will depend on the concentration.
To make •1%(w/v)MB solution what can we use?? water ,Nacl or other liquid for dilution.
It should be 0.1% w/v concentration. Distilled water can be used for dilution. However, if distilled water is not available, dilution with boiled and cooled drinking water is also fine.
how much solution is use in nubilizer.
for sublingual how much dose and it should be diluted or note
Post updated with details.
Pl advise the Quantity/dose of -both sublingual and nebulised MB…what is mentioned in the article is strength(0.1%) but Not the dose..(quantity)
Thanks
Thanks for bringing this to our notice. The post has been updated.
Thanks…noted..
I am in Uganda…we do not have ampoules availabe here..Any idea about using Laboratory grade powder?
.Sir, are treating post Covid patients as well with Fibrosis effects, causing Hypoxia for a long time?
What were your observations in Post Covid fibrosis?
Methylene Blue will help improve post Covid fibrosis. We are going to come out with an article for Post Covid treatment we are seeing a lot of patients with compromised lungs post Covid.
Below is the basic protocol recommended by Dr Golwalkar for post Covid fibrosis (similar to Covid treatment but with a few exercises):
Above will help in improving lung function. However, it will need some time – minimum two months. Practise blowing whistle slowly in one breath. Measure how many seconds you can blow – go on increasing time. For example if 10 seconds today try to make 15 seconds tomorrow. Will help improve lung capacity.
A more detailed post will follow as soon as Dr Golwalkar gets some time.
Reminder….
I am in Uganda…we do not have ampoules availabe here..Any idea about using Laboratory grade powder?
Can we give methylene blue in doses proportional to weight in pediatric ages below 12 years?
Children below 12 years are not in the risk population for Corona. Given that there is limited research available of effects of MB in this age group, use of the same for children should be avoided.
Highly appreciated reaserch and recommadation … May be it will prove to be great help to Mankind in this Padamic period…
I read your wonderful article about treating COVID with MB. I would like to be prepared to use MB in my nebuliser for COVID in case of need. But I am not sure about the dose and the concentration of MB. Could you to tell me the dose and the concentration of MB for nebuliser?
Or i can arrange pick up from ur clinic and m mumbai based.
Comred Medical has it there. It is in Kalana, Bhavnagar.
What is the price? I can get the number of comred medical
What are the brand names available in tablet and solution form
Hello, Dr Golwalkar does not promote any brand. IP grade Methylene Blue in any form that is available will be effective. Please ensure proper concentration as mentioned.
Pl let me know availibility of Methylene blue Tablet
(Preferable in Mumbai)
Kumar
9821846299
As far as we are aware, MB tablets are currently not available in India.
Sir
I did not understand this sentence can u elongate please
swallow what is not absorbed in approx. 30 seconds (2.5 ml)
If you keep it under the tongue for some time; it will be absorbed in 20-30 seconds. Remainder that is not absorbed needs to be swallowed.
Sir.
By which conditions we can disid whether pt.should required MB.and what day we the pt.is indicated MB in covid 19. So inwhich indications pt.have required MB.
We recommend entire unaffected population to be administered 0.1% w/v 2.5 ml MB sublingually. In-case of early symptoms, please start nebulization of MB along with standard Covid protocol.
Sir, what is meaning of BD that you have written in Dosage for patients section. Kindly explain.
Please speak with a doctor and they will explain the same. MB should only be taken under the supervision of a doctor
You can find here the answer:
https://www.quora.com/What-is-the-meaning-of-OD-TDS-and-BD-in-a-doctor-s-prescription
I am not able to find MB is pune either liquid or tablet. Any brand recommended that I can look for online?
Any brand is fine. It may be temporarily out of stock but it should be available soon.
Hello Dr. Deepak, i want the dosage, can you please send the details of how to order or your contact number to call and take the methylene blue to keep below the tongue
કોરોના દદીઁઁ કયા કયા ના સ્ટેજ પર હોય ત્યારે મિથેનબલુ નો કેટલો કેટલો ડોઝ આપવામાં આવેછે
Sublingual Methylene Blue should be taken as a prophylaxis(i.e. Preventive) till pandemic lasts. Nebulized MB to be taken in case of early symptoms. MB is best effective when oxygen saturation is above 93%.
Good for human kind
I have already finished corona 1.5 month back
But still have anxiety & slightly throat discomfort pls suggest
Covid is causing fibrosis of hte lung which is leading to compromised lung and reduced lung capacity after the patients is termed as cured from Covid. We will be publishing Dr Golwakar’s post treatment protocol to help patients who have reduced lung capacity due to Covid-19.
Hello sir,
Can a healthy man take MB to remain safe agaist covid 19 ? I am from Mahuva from where I can get this dose of MB.
I have seen your interview with a news channel. Tv 18 Gujarati. what you are doing is really an act of service
Yes! It is best used as a preventive. Prevention is better than cure especially in case of Covid-19
Dr. It can be taken orally , for senior citizen aged 72 years? Exact qty?
Yes; can be taken. Same quantity as mentioned above. Please ensure that you do not have any of the mentioned contra indications above or are not taking any of the medicines that are contra indicated.
MB has a 120 years of history of use and in our experience, it has rarely had side effects esp. in the mild doses we recommend.
Is it readily available in medical store,how to decide whether to use by nebulizer or to keep it under tounge,In Mumbai is any Dr is using this medicine?
If you do not have Covid-19 symptoms, take sublingual
If you get symptoms, start Nebs. Please note if you have fever, do not wait for report as it can take a few days to confirm if you have Covid or not. The initial few days are precious so start meds ASAP.
Thank u very much Dr Deepak for detailed information on use of MB in covid-19 cases as preventive as well therapeutic adjuvant or add on therapy.
Sir, should sublingual methylene blue taken daily
The frequency and duration of therapy is not mentioned in the post, i think
Thanks for the note doctor. Post updated.
Sir, my father and mother are diabetic. Is 2.5 ml dosage directed by you is safe for them as a preventive measure until covid lasts?
As per many global studies here (and in my expereience); MB actually helps with diabetes esp. if its insulin controlled diabetes.
Thanks sir
I have got MB solution from Bhavnagar, medical store near your clinic.Sir can i keep the bottle in fridge.
MB can be kept at room temperature. No need to freeze it.
Sir
MB in Nebulizer to covid Pts how many days should they take?
And Nebulizer of MB should give to non covid pts? I mean normal person should take Nebulizer of MB or just sublingual is good?
Sublingual Methylene Blue for unaffected population OD
Sublingual + Nebs for people with symptoms; in case you have symptoms please do not wait for reports to come; initial few days are very crucials and reports are still not very accurate.
Thank you sir for your reply
I am searching for MB injection in Rajkot but couldn’t find it
Is there any contact you have in Rajkot so I can get it or else give me the contact in Bhavnagar so I can get Cureir
For prophylaxis it is written: “Sublingual administration of 0.1% w/v concentration daily (till the pandemic lasts) — swallow what is not absorbed in approx. 30 seconds (2.5 ml)”
My question: once a day or BD?
OD. Updated the blog with the details. Thanks for highlighting.
Dear Doctor,
Methylene Blue is available in homiopathic stores as
Methylene Blue Dilution 200 CH bottle of 100ml dilution,
with different CH and dilution, can this also be used as Prophylaxis, if yes what can be the dosages?
Hello, we recommend using IP/USP grade medicines. We do not have much experience in using MB from Homeopathic stores.
I found this one online – do you think it is the correct one?
https://amber-technologies.myshopify.com/products/mb-cure-methylene-blue
Yes the link is correct. Shipping is a bit slow but I got the order delivered in 5 days to Mumbai.
Dear Doctor,
Thanks for your valuable input and time.
If possible , may pls find out the dosage and potency of MB grade.
Thanks.
Hi, my father got discharge from hospital (covid-19) a week ago.. he takes oxygen at 2 lpm, does breathing excercises at home. Diet is coming to normal. What MB treatment can be suggested by doctor or can we talk to him over phone in this regard ? I am from bharuch.
If there is lung fibrosis MB will help reduce it. However, it is difficult to comment based on the information you have provided.
Sir, Pls give the link to your blog on MB usage for COVID-19.
Sir what is the dosage for the infected person of MB.?
Thank u very much Dr Deepak for detailed information on use of MB in covid-19 cases as preventive as well therapeutic adjuvant or add on therapy.
Reminder….
I am in Uganda…we do not have ampoules availabe here..Any idea about using Laboratory grade powder?
Sir my wife diabetic and on insulin ..from 4 years aged 48..
My father have bp aged 82 ..still hale and healthy..
Along with them all of us are above 15 years ..
Can we take mb sublingual as per your instructions as preventive measures against covid-19..
Thank you
Yes. MB is not contraindicated in any of the above 2 cases. Incidentally, MB has benefits for Diabetes too – though still more research is ongoing.
I think with the following Amazon you get the solution delivered
https://www.amazon.in/dp/B08GL3KFHP
Dr Golwalkars clinic is a sea of humanity. THis is my experience.
We reached early as we were aware that hte rush increases. Its a small clinic and I guess it was never built for this scale, but here goes. The staff was yet to come in, so some patient took out a page from his notebook and just started writing down names. As patients came, they wrote their names down.
When the staff comes, it does get a bit chaotic as people start moving. Someone is sent for X Rays, some for reports and some just trying to find a good place to sit. My turn was 9th in the queue so luckily I could meet the doctor relatively soon.
He has a small cabin and there are a lot of patients; but he is very fast. Best thing is, he doesn’t scare you like other doctors do. He went through my X Rays and I was out of his cabin in 10 mins.
Feedback
– Please don’t expect 5 star clinic; its a traditional clinic with a very experienced doctor
– Money doesn’t get you anywhere here – you have to wait your turn even if you are a son of a MLA (we had one in our queue who tried to get in first but )
– The doctor should increase seating space and improve ventilation
– There needs to be better organization since there are so many patients coming (on teh day I had gone, I was lucky – I think close to 100 patients were turned away as there was no room left)
– The govt. should take note – if so many patients believe his medicines work – why isn’t the govt. supporting?
Preparation of 0.1% MB solution : 1 ml methelyne blue injection added in 1000ml (1liter) distilled water or (bolied and cooled water). Is this preparation ok?
Hello Dr,
I am a Pathologist in a remote town, can we prepare 0.1 % solution of MB from Reagent grade powder marketed by Merck?
We recommend using IP/USP grade powder as we are not sure about purity of other powders in the market.
Dear Doctor
My father has undergone stent surgery 1.5 year ago when he suffered a heart attack. can i give hime MB as prescribed by you. 0.1%
Yes can be given. Not contra indicated.
I want ready to use liquid for my father. They are diabetic. High blood pressure patient.
Can take Methylene Blue; not contraindicated.
Sir,
How can I contact you.
My WhatsApp number is 9558818402.
Request you to send me detail information
Currently, we are struggling with a very high case load and are unable to attend calls. However, Dr Golwalkar is having educational sessions with other doctors and general public.
You can attend the same here : https://bit.ly/2YKH25O @ 11 AM on 30th Aug.
Dear sir, we are treating covid ICU cases. I request you to please guide me , about shall I take MB regularly, shall we administer it to our ICU cases and dosage also. You are doing a great work to human kinds sir.
Pls guide me , Shaall I use it for my wife (39yr old and no any disease), and for my kids 12yr and 9yr old…
Yes; we recommend all doctors treating Covid19 to take the prophylaxis dosage mentioned above.
Also, for patients please administer MB sublingual and Nebs as soon as possible. Covid19 is a very fast acting disease; so the sooner we can administer MB the better the final outcome.
Children are not in the risk population (we’ve not received a single child with severe Covid19 symptoms in last 4 months) and we do not advise for children below 12 year.
Dear Sir
Your work is great and with simplicity. Today I attended your session also. It was for Doctor but still it was very useful. Sir please guide how many minutes nebulizer should be taken. Will you please put your video on how to take dose and how to take nebulizer on you tube in hindi language so we can forward it to many people. Thank you once again.
For symptomatic patients, 5 ml bd nebulization is fine. On case by case basis we may increase it upto 10 ml however, its best left to the treating physician to decide.
We are trying to get a few videos and sessions uploaded; however given the limited time and resources its providing difficult for us.
Thank you sir. How can I support you in making video or in any other way. I am at Surat. I am sharing my cell number on your email ID. Already I had forwarded your TV9 interview to my various friend, but I want to make more informative and easy to understand video. How to make MB does at home etc. with your support and guidance if you permit. No business motive behind it but sharing information to all.
Dear sir,
I take a one dose of methylene blu 2.5 ml of sublingual, and got greenish urination as its common side effects..
Can I skip taking it or no need to worry about green urination… And continue the use of it…
Known side effect. Please check list of side effects above.
Can i continue the use of mb after this or skip it…
Mb 2.5 ml જ્યાં સુધી આ epidemic છે ત્યાં સુધી રોજ લેવું સારું કે જ્યારે ઇન્ફેક્શન લાગે ત્યારે તરતજ ચાલુ કરી ને 10 કે 15 દિવસ સુધી લેવું સારું.પ્લીઝ જણાવજો.
Till the pandemic lasts. Our hope is that atleast in city like Bhavnagar where the use is widespread we will be able to get it under control soon.
Hello sir. I want to try MB for my father who is having Idiopathic Pulmonary Fibrosis, appx affecting 25% of both lungs more on rt side…0.1 % MB nebuliz form 5 ml as u mention should be fine? He is having duolin ,foracort, prednisone 20 od ,perfenidone for fibrosis…I m Pediatrician…is there any risk of bronchospasm ?
Since this is a very specific case, we request you please have him checked with a Pulmonologist once before administration. It would be difficult to advise without complete clinical history and examination of the patient.
Dr. Gowlankar Sir,
I want to purchase this solution from your clinic. Please guide sir..how to pay and deliver details..
Dr i am diabetic patient.79 yr old.female….upto what levels of e-gfr levels you suggest.that mehylene blue can be taken safely as my kidney functions are down..upto27 to 30 levels
Can i take half dose 1.25 ml only to avoid its toxicity.
Renal issues are contraindicated for Mehtylene Blue; please take only under strict medical supervision.
Dear Doctor
I have MB injection of 10ml that each ml contain 10mg MB.
to prepare 0.1% solution i mixed 100ml distilled water + 10ml Injection (10mg/ml)
is it right?
In the published paper by Dr Golwalkar on May 8 2020, It is stated that
“In India, you can get IP grade 1% Methylene Blue injections for as low as $1. Since its a very powerful drug, this much quantity will need to be diluted by over 10 times. So potentially, you can prepare over 10 doses in $1 to get a 0.1% concentration. The concentration needed in nebulized form.
In the USA, MB injections are costlier (around $30); howsoever, they are still cheaper than other Vaccines being promoted. And the same economics will work there — 10 doses for $30 which is cheaper than other alternatives being proposed.” Looking to this statement You are right. I am using this solution ( 10 ml MB injection + 100 ml water)
What is the price? I can get the number of comred medical
My uncle has rhumethoid arthritis , blood pressure , diabetes and he is taking immunosuppressive medicine
So he can take methylene blue for preventing covid19
While on the face of it none of this looks contraindicated for MB, we request you to please speak with a Pulmonologist with your case history for better advise.
Heart blockage is 40% so can take mb to prevent covid 19
Not contraindicated but please speak with your doctor before taking Methylene Blue. Need to understand all medication you are under.
Minimum dosage recommendations for Methylene Blue is 0.5mg Per Kg Per Day… But your dosage of 2.5ml 0.1% solution is equivalent to 2.5mg Methylene Blue. It is a very very low dose..
is it enough as a prophylactic??
normal 70kg person would require 35mg dose.
There are many studies that says MB inactivates SARS and Covid viruses. Here’s a link that says 5 micromole/litre MB inactivates 6.5 log in 3 minutes. https://europepmc.org/article/cba/518857
Based on the above, below is the calculation that confirms 2.5 ml is more than sufficient.
Good evening sir,we are in joint family of 8,out of this 2 are positive,
1.we can nebulize them with one nebulizer?
2.others will take mb sublingualy,but if someone is asymptometic what we should do,nebulize them or not?
Thanks