sursa: https://medium.com/@dr.deepak.golwalkar/methylene-blue-dosage-for-patients-for-prophylaxis-71aee5f979f6

Methylene Blue dosage for Patients & for Prophylaxis

Jul 30 · 2 min read

Many people have written asking for the dosage for MB(Methylene Blue) with nebulizer — so creating this post to help everyone in this time of need.

Important Note

Methylene Blue is toxic in incorrect dosages so please do not self administer it (it should only be administered by a certified medical practitioner)
Methylene Blue must not be administered to pregnant or lactating mothers (it can be harmful to the fetus; data for feeding mothers is not available)
Methylene Blue should not be administered who have known reported hypersensitivity to MB, G6PD deficiency, cronic/acute liver dysfunction or severe renal impairment
Methylene Blue should not be administered to children below 12 years of age (insufficient data available)
Methylene Blue is an add on therapy to conventional line of treatment
Only IP or USP grade Methylene Blue to be used

Dosage

MB shows best results when used as a prophylactic and in the early stages of the disease (when spO2 is above 92–93%). In severe cases its administration as an add on therapy significantly improves final outcomes.

Dosage for Prophylaxis

MB shows best results as a prophylactic & should be considered as the primary line of administration in the general unaffected population.

Sublingual administration of 2.5 ml of 0.1% concentration daily (till the pandemic lasts) — swallow what is not absorbed in approx. 30 seconds

Dosage for Patients

In affected patients in their early stage of the disease (spO2 more than 92%); Nebulized MB is a supportive line of treatment and has shown to improve the final clinical outcome.

One ampule of Dexona + one ampule Duolin in nebulized form BD
MB in nebulzed form 0.1% of 10 m.l. BD (NOT to be mixed with Dexona + Duolin)
Post recovery, continue to administer MB Nebulizer OD till 6 minute walk test is normal

Side Effects

As MB has a strong blue color, the face will show blue coloration on Nebulization which is temporary
MB has a bitter taste so some patients may complain of the same
Some patients report a bluish green tinge in their urine
Some patients may complain about irritation in the nose post nebulized administration

Important Notes

Methylene Blue is toxic in incorrect dosages so please do not self administer it (it should only be administered by a certified medical practitioner); dosage should be only as directed
Methylene Blue must not be administered to pregnant or lactating mothers (it can be harmful to the fetus; data for feeding mothers is not available)
Methylene Blue should not be administered who have known reported hypersensitivity to MB, G6PD deficiency, cronic/acute liver dysfunction, cyanide poisoning or severe renal impairment
Methylene Blue should not be administered to children below 12 years of age (insufficient data available)
Methylene Blue is an add on therapy to conventional line of treatment
Only IP or USP grade Methylene Blue to be used

Reactions with other medicines

1. Bupropion,Fluoxetine,Selegiline
2. Clomipramine,Milnacipran,St. John’S Wort
3. Doxepin,Mirtazapine,Trazodone
4. Duloxetine,Rasagiline,Tryptophan
5. Certain Medicines For Depression Or Anxiety,  
6. Maois Like Marplan Nardil And Parnate

Reaction of Methylene Blue with other medicines

References

Orignal Post : https://medium.com/@dr.deepak.golwalkar/treatment-for-covid-19-using-methylene-blue-d23fc5a31a4d

https://my.clevelandclinic.org/health/drugs/20577-methylene-blue-tablets4

WRITTEN BY

Grădina