For the information and comments of all my Doctor Seniors, Batchmates, friends, and Juniors.....
Treatment for COVID-19 using Methylene Blue : Courtesy Dr.Deepak Golwalkar
Pulmonologist
Using Methylene Blue in nebulized form for treating patients with Coronavirus (Covid-19)
As COVID-19(Coronavirus) ravages the world, a quick, novel, cost effective cure for this malaise has been found to be very effective.
Being a pulmonologist (lung specialist) in India, Dr.Deepak Golwalkar
Pulmonologist, has been treating pneumonia, other respiratory ailments and Tuberculosis patients with XDR & MDR TB for more than 42 years.
Dr.Deepak Golwalkar
Pulmonologist has achieved remarkable success in treating his patients with Methylene Blue and with documented evidence.
When used in sub lingual and nebulised form
Methylene Blue helps remarkably in clearing alveolar capillary blocks.
Covid causes a silent hypoxia wherein patients despite having acute hypoxia which is low oxygen saturation (spO2) show no clinical symptoms.
Patient is not dyspneic in spite of having very low oxygen saturation. These soon escalate to a cytokine storm and patient goes in the irreversible phase of the respiratory distress.
Covid patients show resemblance to methemoglobinemia.
Methylene Blue is considered as an approved drug of choice for methemoglobinemia.
Additionally, Methylene Blue has a strong antifibrotic action and is very fast acting anti inflammatory.
Given the above presentations, Methylene Blue can be used as a treatment to all Coronavirus symptomatic patients & as a prophylactic drug to all vulnerable population.
Used in low dosage as prescribed below, it shows no significant side effects with only less than 2% of patients complained of irritation in the nose with or without nausea for a day which subsided on its own.
Given its low cost, it is also a viable regime for poorer countries like India.
A number of patients with varying levels of respiratory distress have been treated using Methylene Blue in nebulised /sub-lingual form over the course of his years of practice.
Potential Treatment regime for the novel Coronavirus Covid-19 :
Primary course of administration is in Nebulized form and Sublingually together.
For patients with severe Cyanosis when oxygen levels is less than 85%, IV administration may be required based on the clinical condition of the patient.
Administration steps as below under medical supervision only since Methylene Blue is known to be toxic in incorrect dosages.
0.1% Methylene Blue to be administered as inhalation through a nebulizer - Primary line of treatment
Nebulization to be given through a nasal mask
Sublingual administration will be as a supportive line of treatment for A person wearing a nebulizer and ideal way
Post his recommendations, a hospital in Mumbai started administering Methylene Blue through Nebulizer as well as sublingually on COVID-19 confirmed patients with positive results.
Methylene blue (Methylthioninium Chloride) is a thiazine dye & a medication. It is easily available in drug stores across India. It is safe to consume in low dosage of less 2 mg/kg in IV form under proper medical supervision.
It was the first antiseptic dye to be used therapeutically and it is present on WHO Model List of Essential Medicines.
In fact, its use was widespread even before the advent of sulphonamides and penicillin.
Its benefit is, it rapidly arrests fibrosis which proves beneficial against virulent strains.
Update on why Methylene Blue works :
There are multiple reasons why Methylene Blue is effective ; the chief is Nitric Oxide mediated reduction in inflammatory cascades in addition to inhibiting canonical inflammasomes.
Radiologically (i.e. X Ray) Covid/Swine Flu are similar & resemble any acute viral/fungal loefflers or aspiration pneumonia.
Clinical distinction can be made by giving intranasal oxygen — you’d notice an improvement in normal pneumonia but not for Swine Flu or Covid-19 as these viruses would lead to alveolar capillary blockage (i.e. blocking the ability of the lungs to operate in simple words).
Methylene Blue clears the blockage within 24 hours and Oxygen levels starts improving.
Covid-19 is a more virulent strain compared to H1N1 and a fast acting drug is necessitated.
Due to the clinico/pathological resemblance between H1N1 & Covid-19 — final outcome is expected to be similar post administration of Methylene Blue.
Dr Deepak Golwalkar
Pulmonologist, practicing since 42 years, a Pioneer in using Methylene Blue in Nebulised form for lung diseases since 2001
e-mail to Dr.Deepak Golwalkar
Pulmonologist, through his e-mail ID : dr.deepak.golwalkar@gmail.com
My sincere thanks to Dr.P.Rajashekar for enlightening me and his enthusiastic advice for sharing to my Doctor Seniors, Batchmates, friends and Juniors.
Palanisamy ASPA
The Pharmacist Who Knows and Cares
